HO-PEG-CH2COOMe

Alpha-(hydroxy)-omega-(methyl-protected carboxymethyl) poly(ethylene glycol) (HO-PEG-CH2COOMe) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear hydroxyl and methyl-ester-protected carboxymethyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The methyl ester remains available for subsequent ester transformations, allowing a conjugatable carboxyl group to be introduced after other linking steps. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.