HO-PEG-Glycidyl

Alpha-(hydroxy)-omega-(glycidyl ether) poly(ethylene glycol) (HO-PEG-Glycidyl) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear hydroxyl and glycidyl ether groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The epoxide can undergo ring-opening addition with suitable nucleophiles, such as amines or thiols, for subsequent segment linking and material crosslinking. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.