HO-PEG-NHMe

Alpha-(hydroxy)-omega-(methylamino) poly(ethylene glycol) (HO-PEG-NHMe) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear hydroxyl and methylamino groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The secondary amine can participate in suitable acylation or other amine reactions, enabling comparisons of amine substitution and conjugation routes. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.