H2N-PEG-NHBoc

Alpha-(amino)-omega-(tert-butoxycarbonyl-protected amino) poly(ethylene glycol) (H2N-PEG-BocNH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear primary amine and Boc-protected amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.