H2N-PEG-NHCbz

Alpha-(amino)-omega-(benzyloxycarbonyl-protected amino) poly(ethylene glycol) (H2N-PEG-CbzNH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear primary amine and Cbz-protected amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The Cbz-protected end retains a releasable amine precursor, allowing amine coupling and transformations at the other terminus to be performed sequentially. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.