HS-PEG-CH2COOMe

Alpha-(sulfanyl)-omega-(methyl-protected carboxymethyl) poly(ethylene glycol) (HS-PEG-CH2COOMe) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear thiol and methyl-ester-protected carboxymethyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The thiol can add to maleimides or participate in disulfide formation, offering different molecular conjugation routes. The methyl ester remains available for subsequent ester transformations, allowing a conjugatable carboxyl group to be introduced after other linking steps. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.