FmocNH-PEG-CH2COOH

Alpha-(fluorenylmethoxycarbonyl-protected amino)-omega-(carboxy) poly(ethylene glycol) (FmocNH-PEG-COOH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear Fmoc-protected amine and carboxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. Fmoc protection facilitates sequential conjugation. Amine coupling can follow deprotection under conditions compatible with the target system. The carboxyl group can be activated for amide coupling with primary-amine-containing molecules, retaining a handle for subsequent ligand or carrier attachment. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.