CH2COOH-PEG-NHCbz

Alpha-(carboxymethyl)-omega-(benzyloxycarbonyl-protected amino) poly(ethylene glycol) (HOOCCH2-PEG-NHCbz) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear carboxymethyl and Cbz-protected amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The carboxymethyl group can be activated for coupling with primary amines. Its single methylene group defines the local connection between the reactive carboxyl group and the polyether chain. The Cbz-protected end retains a releasable amine precursor, allowing amine coupling and transformations at the other terminus to be performed sequentially. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.