CH2COOH-PEG-CH2COOH

Alpha,omega-bis(carboxymethyl) poly(ethylene glycol) (HOOCCH2-PEG-CH2COOH) is a homobifunctional precision PEG derivative with a defined chain length. Both ends bear carboxymethyl groups. Discrete chain lengths with different degrees of polymerization are available. The carboxymethyl group can be activated for coupling with primary amines. Its single methylene group defines the local connection between the reactive carboxyl group and the polyether chain. Identical reactive sites at both ends support molecular bridging or derivatization on both sides. The conjugation scheme can be designed around the number of target sites.

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