HOOCCH2CH2-PEG-CH2CH2COOH

Alpha,omega-bis(carboxyethyl) poly(ethylene glycol) (HOOCCH2CH2-PEG-CH2CH2COOH) is a homobifunctional precision PEG derivative with a defined chain length. Both ends bear carboxyethyl groups. Discrete chain lengths with different degrees of polymerization are available. The carboxyethyl group can be activated to couple with amine-containing components. Its two methylene groups provide a local spacer distinct from a carboxymethyl linker. Identical reactive sites at both ends support molecular bridging or derivatization on both sides. The conjugation scheme can be designed around the number of target sites.

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