CH2COOH-PEG-CH2CH2COOH

Alpha-(carboxymethyl)-omega-(carboxyethyl) poly(ethylene glycol) (HOOCCH2-PEG-CH2CH2COOH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear carboxymethyl and carboxyethyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The carboxymethyl group can be activated for coupling with primary amines. Its single methylene group defines the local connection between the reactive carboxyl group and the polyether chain. The carboxyethyl group can be activated to couple with amine-containing components. Its two methylene groups provide a local spacer distinct from a carboxymethyl linker. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.