NHSOOCCH2-PEG-NHBoc

Alpha-(carboxymethyl N-hydroxysuccinimide ester)-omega-(tert-butoxycarbonyl-protected amino) poly(ethylene glycol) (NHSCOCH2-PEG-NHBoc) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear carboxymethyl NHS ester and Boc-protected amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The carboxymethyl NHS ester can directly couple to primary-amine-containing components, enabling comparisons of the short spacing between the activated site and the polyether chain. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.