NHSOOCCH2-PEG-NHFmoc

Alpha-(carboxymethyl N-hydroxysuccinimide ester)-omega-(fluorenylmethoxycarbonyl-protected amino) poly(ethylene glycol) (NHSCOCH2-PEG-NHFmoc) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear carboxymethyl NHS ester and Fmoc-protected amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The carboxymethyl NHS ester can directly couple to primary-amine-containing components, enabling comparisons of the short spacing between the activated site and the polyether chain. Fmoc protection facilitates sequential conjugation. Amine coupling can follow deprotection under conditions compatible with the target system. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.