BocNH-PEG-NHFmoc

Alpha-(tert-butoxycarbonyl-protected amino)-omega-(fluorenylmethoxycarbonyl-protected amino) poly(ethylene glycol) (BocNH-PEG-NHFmoc) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear Boc-protected amine and Fmoc-protected amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. Fmoc protection facilitates sequential conjugation. Amine coupling can follow deprotection under conditions compatible with the target system. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.