BocNH-PEG-NHCbz

Alpha-(tert-butoxycarbonyl-protected amino)-omega-(benzyloxycarbonyl-protected amino) poly(ethylene glycol) (BocNH-PEG-NHCbz) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear Boc-protected amine and Cbz-protected amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The Cbz-protected end retains a releasable amine precursor, allowing amine coupling and transformations at the other terminus to be performed sequentially. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.