CH2COOtBu-PEG-CH2COOtBu

Alpha,omega-bis(tert-butyl-protected carboxymethyl) poly(ethylene glycol) (tBuOOCCH2-PEG-CH2COOtBu) is a homobifunctional precision PEG derivative with a defined chain length. Both ends bear tert-butyl-ester-protected carboxymethyl groups. Discrete chain lengths with different degrees of polymerization are available. The tert-butyl ester temporarily protects a carboxyl precursor. Appropriate acidic deprotection enables subsequent carboxyl activation and amide coupling. Identical reactive sites at both ends support molecular bridging or derivatization on both sides. The conjugation scheme can be designed around the number of target sites.

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