CH2CONHH2N-PEG-CH2CONHNH2

Alpha,omega-bis(carboxymethyl hydrazide) poly(ethylene glycol) (H2NNHCOCH2-PEG-CH2CONHNH2) is a homobifunctional precision PEG derivative with a defined chain length. Both ends bear carboxymethyl hydrazide groups. Discrete chain lengths with different degrees of polymerization are available. The hydrazide can condense with aldehydes or ketones to form hydrazone bonds. The carboxymethyl moiety retains a short spacer to the polyether chain. Identical reactive sites at both ends support molecular bridging or derivatization on both sides. The conjugation scheme can be designed around the number of target sites.

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