HO-PEG-CH2CONHNH2

Alpha-(hydroxy)-omega-(carboxymethyl hydrazide) poly(ethylene glycol) (HO-PEG-CH2CONHNH2) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear hydroxyl and carboxymethyl hydrazide groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The hydrazide can condense with aldehydes or ketones to form hydrazone bonds. The carboxymethyl moiety retains a short spacer to the polyether chain. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.