Mal-PEG-CH2CH2COOH

Alpha-(maleimide)-omega-(carboxy) poly(ethylene glycol) (MAL-PEG-COOH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear maleimide and carboxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The carboxyl group can be activated for amide coupling with primary-amine-containing molecules, retaining a handle for subsequent ligand or carrier attachment. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.