PhthN-PEG-CH2CH2COOH

Phthalimido-poly(ethylene glycol)-propionic acid (PhthN-PEG-CH2CH2COOH) is a family of heterobifunctional precision PEG derivatives with defined chain lengths. One end is a phthalimide-protected structure linked through nitrogen to the carbon chain at the PEG terminus. The other is a propionic acid terminus of the form PEG-O-CH2-CH2-COOH. The carboxyl group can first be activated to form an amide with a primary-amine-containing molecule. The protected amine end retains a reaction site for subsequent sequential conjugation. Removal of the phthaloyl group under appropriate conditions yields the corresponding amino-PEG-propionic acid derivative. This series distinguishes discrete chain lengths by degree of polymerization, enabling comparisons of PEG spacer length in molecular conjugation and derivatization.

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