8-Arm-PEG-CH2CH2COOH

8-Arm carboxylic acid-functionalized discrete poly(ethylene glycol) (8-Arm-PEG-COOH) is an 8-arm precision PEG derivative. The PEG arms present terminal carboxyl groups. Discrete chain lengths with different degrees of polymerization are available. The carboxyl group can be activated for amide coupling with primary-amine-containing molecules, retaining a handle for subsequent ligand or carrier attachment. The multiarm structure provides attachment sites for multivalent ligand display or network construction. Arm number, chain length, and functional-group equivalents can be varied to compare crosslink spacing and molecular presentation. In this series, n denotes the number of ethylene glycol repeat units in each PEG arm.

Customization available.