DBCO-PEG-DSPE

Dibenzocyclooctyne-poly(ethylene glycol)-1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DBCO-PEG-DSPE) is an amphiphilic PEG lipid combining a di-C18 acyl phospholipid anchor with a defined-length hydrophilic PEG segment. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. It can be used to construct interfaces in membrane-related systems and nanoparticle formulations, enabling comparisons of anchoring structure, hydrophilic chain length, terminal functionality, and formulation dispersion.

Customization available.