TCO-PEG-DPPE

Trans-cyclooctene-poly(ethylene glycol)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine (TCO-PEG-DPPE) is an amphiphilic PEG lipid combining a di-C16 acyl phospholipid anchor with a defined-length hydrophilic PEG segment. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. It can be used to construct interfaces in membrane-related systems and nanoparticle formulations, enabling comparisons of anchoring structure, hydrophilic chain length, terminal functionality, and formulation dispersion.

Customization available.