Formylphenylboronic acid-functionalized poly(ethylene glycol)-1,2-distearoylglycerol (FormPBA-PEG-DSG)

Formylphenylboronic acid-functionalized poly(ethylene glycol)-1,2-distearoylglycerol (FormPBA-PEG-DSG) is a family of precision PEG lipids combining a dual-C18:0 glycerolipid anchor, a defined-length PEG spacer, and an aldehyde-functional phenylboronic acid headgroup. Two stearoyl chains are ester-linked to a glycerol scaffold. PEG is attached to the aryl headgroup through a phenoxyacetamide segment, and the aldehyde and boronic acid groups occupy adjacent positions on the aromatic ring. The aryl terminus has adjacent aldehyde and free boronic acid groups, combining carbonyl derivatization and boronic acid–diol interactions for bifunctional interface design. Different PEG degrees of polymerization are available within the series, enabling comparisons of hydrophilic spacer length while keeping the lipid anchor and aryl headgroup unchanged. Pairing with the DMG counterpart also allows fatty-acyl chain length to be studied as a structural variable.

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