Formylphenylboronic acid pinacol ester-functionalized poly(ethylene glycol)-1,2-distearoylglycerol (FormPBE-PEG-DSG)

Formylphenylboronic acid pinacol ester-functionalized poly(ethylene glycol)-1,2-distearoylglycerol (FormPBE-PEG-DSG) is a family of precision PEG lipids bearing aldehyde and protected arylboronic acid sites. The molecule consists of a 1,2-distearoylglycerol anchor containing two C18:0 stearoyl chains, a defined-length PEG spacer, and an aldehyde-containing phenylboronic acid pinacol ester headgroup. PEG is attached to the aromatic ring through a phenoxyacetamide linking segment. The aldehyde and boronate ester groups occupy adjacent ring positions. The aryl terminus retains both an aldehyde and a boronic acid pinacol ester. The aldehyde provides a carbonyl-derivatization handle, while the pinacol ester provides a protected boron group for sequential construction of a functional headgroup. PEG degree of polymerization and subsequent headgroup transformations can be selected separately to study the interplay of the hydrophobic anchor, hydrophilic spacer, and reactive sites, with the corresponding free boronic acid series serving as a structural comparison.

Customization available.